Genome analysis of a plasmid-bearing myxobacterim Myxococcus sp. strain MxC21 with salt-tolerant property

Myxobacteria are widely distributed in various habitats of soil and oceanic sediment. However, it is unclear whether soil-dwelling myxobacteria tolerate a saline environment. In this study, salt-tolerant myxobacterium Myxococcus sp. strain MxC21 was isolated from forest with NaCl tolerance >2% concentration. Under 1% salt-contained condition, could kill consume bacteria prey exhibited complex social behaviors such as S-motility, biofilm, fruiting body formation but adopted an asocial living pattern the presence 1.5% NaCl. To investigate genomic basis stress tolerance, complete genome sequenced analyzed. Strain consists circular chromosome total length 9.13 Mbp plasmid 64.3 kb. Comparative analysis revealed that genomes M. xanthus DK1622 share high synteny, while no endogenous found DK1622. Further showed approximately 21% its coding genes predominantly associated signal transduction, transcriptional regulation, protein folding involved diverse niche adaptation salt which enables behavior gliding motility, sporulation, predation. Meantime, number also to be defense against oxidative production antimicrobial compounds. All these functional may responsible for potential salt-toleration. Otherwise, second reported containing indigenous plasmid, only small proportion specific MxC21, most them were annotated hypothetical proteins, have direct relationship habitat under This study provides inspiration adaptive evolution facilitates application improvement future.